Description
Resistin-Like Molecule-beta (RELM- β) is a member of a recently identified family of secreted proteins containing conserved cysteines in their C terminus. The RELM family consists of Resistin (also called FIZZ3), RELM-α (FIZZ1), and RELM-γ. Only Resistin and RELM-β were found in humans whereas all four RELM family members have been identified in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodelling and increased inflammation